Set in a lavish mansion, Chandramukhi 2 follows a wealthy family facing a peculiar problem involving a vengeful spirit that haunts their ancestral home. To appease the spirit and solve the mystery, they enlist the help of a doctor and a dancer who shares a striking resemblance to Chandramukhi, the spirit's former self. Their quest involves unraveling a tragic past and confronting the entity that has held the mansion captive for years.